The article presents authors’ generalization of the methods used for the inventory of pollutant emission from civilization-related sources. The study has been illustrated with results of an evaluation of the share of road transport in pollutant emission from civilization-related sources in Poland in 2015 with respect to the contribution of road transport to total pollutant emission. Official results of an inventory of the emission of substances harmful to health of living organisms, carried out by the National Centre for Emissions Management (KOBiZE) at the Institute of Environmental Protection – National Research Institute, have been presented. The said results are reported in the European Union. They pertain to the civilization-related sources classified as in SNAP (Selected Nomenclature for sources of Air Pollution). It has been found that among the most important environmental hazards related to the emission of substances harmful to health from civilization-related sources, road transport is chiefly accountable for nitrogen oxides emission; however, the national annual emission of nitrogen oxides in Poland has been decreasing from as long ago as 2007, in spite of a significant growth in the number and intensity of use of motor vehicles. The contribution of motorization to the air pollution with particulate matter is relatively small. Definitely, dusts are predominantly emitted by the power industry, especially the dispersed emission sources. Road transport has been found to emit particularly small quantities of one of the most harmful air pollutants, i.e. sulphur oxides. This has been achieved thanks to widespread introduction of low-sulphur fuels. Thanks to the introduction of unleaded fuels to general use, only trace influence of road transport on lead emission has been recorded.