With the introduction of the concept of the industry 4.0, automation, robotics, artificial intelligence, communication methods, automotive engineering, mechanics, construction and operation of automotive vehicles, and so on, as well as the methods of corporate management are changing. Following this concept, new risks emerge, when workers have to cooperate with collaborative robots, autonomous systems, artificial intelligence, machine learning and learn new methods different from previous processes and systems. The paper first presents the theoretical background related to the topic addressed. The next sections encompass the literature review, including a list of references relevant to achieving the main objective of the paper, as well as a description of the research methods used in the paper. With regard to the main objective, quantitative research concerning the vehicle construction systems' safety issues in industry 4.0 was conducted; i.e., a questionnaire survey was developed within a sufficiently representative sample of respondents. After conducting the survey, the risk assessment model of vehicle construction systems' safety under the conditions of Industry 4.0 was proposed while applying the principles of system dynamics. An integral part of the paper is represented by the discussion of the obtained results and benefits, as well as the formulation of relevant conclusions.